We have developed and implemented a haptic robotic training system into Hershey Medical Center’s surgical resident training program. This device utilizes a haptic robot and virtual ultrasound image to provide diverse patient scenario training of ultrasound guided central venous catheterization. This project explores both the interaction between soft tissue and instruments and how to most effectively train the complex skills needed by future surgeons.
In ten years, many more Americans will die from drug resistant infections than will die in car crashes -- if nothing is done. Turning that situation around will require interdisciplinary effort, not unlike that responsible for the massive improvements in road safety. But right now, the resistance problem seems a lot harder.
Tools for reconstructing complex carbonaceous-rich structures with partial ordering are lacking. We have created a series of image analysis and atomistic construction approaches to allow HRTEM micrographs to be used for image-guided, large-scale construction of atomistic representations (>30,000 carbon atoms) with consideration of the distribution of alignment, order (stacking), lattice fringe size, and initial efforts for defect-induced graphene curvature.
Metal ions in enzyme active sites catalyze many of Nature’s most challenging and important reactions, from synthesis of the building blocks of DNA to photosynthesis and respiration. Selective incorporation of the correct metal ion into an enzyme is usually crucial for function, and a major interest of my lab is how cells control metal ion localization to ensure this selectivity and how misregulation of those pathways leads to disease. I will present my lab’s progress toward developing protein- and nucleic acid-based fluorescent sensors for iron and manganese, sensors which we envision applying to better understand the dynamics of these metals in mammalian, bacterial, and host-pathogen systems.
Based upon feedback provided during the Millennium Café SWOT analysis last month we are soliciting ideas for “Grand Challenge” talks at the Café over the next 12 months. The desire is to have one of these talks each month and the format is TBD but could involve having up to 3 presenters cover a single topic from different angles and then opening the floor up for a panel type discussion (see below for one example from a previous Café talk).
Please send ideas directly to Josh Stapleton by July 31st.
Bacteria typically extract energy from their environment by transferring electrons from organic compounds to molecular oxygen. In oxygen-deficient deepwater lakes, a certain bacterium known as Shewanella oneidensis transfers these electrons instead to iron oxide or manganese oxide nodules using electrically-conductive wires that extrude from the cell. These bacteria are being employed commercially in bacterial fuel cells to generate electricity from waste water. In this talk, I will discuss the composition of these electrically-conductive wires and speculate on how they might be useful in cell-to-cell communication for biofuel production.
Emerging and re-emerging human pathogenic viruses such as Chikungunya, West Nile, dengue and Zika cause frequent outbreaks across the globe. Despite the urgent medical need to control these arthropod-borne (arbo) virus infections, there are no licensed human vaccines or specific antiviral therapy available. We are utilizing high-resolution, live-cell imaging coupled with single particle tracking, and electron microscopy analyses to elucidate complex networks of virus–host protein associations in virus life cycle. One of our major objectives is to garner greater insights into how these pathogens exploit host pathways for entry, replication, assembly and subversion of host defenses.
Bees are critical pollinators of agricultural crops, but populations of both managed and wild pollinators are in decline globally. Penn State’s Center for Pollinator Research represents the largest consortium in the world of researchers, educators, extension specialists and outreach coordinates tackling issues related to pollinator decline, management and biology. Multiple interacting factors are driving pollinator declines, many of which are associated with biotic and abiotic features of the landscape, including the availability of forage, pesticide use, population densities, and climate. We are coupling information on honey bee population health with landscape information to develop predictive models of bee health. Our goal is to develop a web-based tool that beekeepers, land managers, growers, and policymakers can use to evaluate the quality of their landscapes for supporting bee populations and obtain recommendations for improving their landscapes and management practices.
Exploding traditional disciplinary boundaries, Cristin Millett’s investigations of medicine and its history are integral to her artistic process. Her research stems from her childhood growing up in a medical household where discussions focused on the human body. Whereas most scholars respond to their research through writing, Millett expresses the results of her critical analysis by creating works of art. She reinvents established methods of sculpture by incorporating new advances in digital technology, including CNC machining, 3D printing, and robotics, with the time-honored practices of stone carving and bronze casting. Her objects and installations prompt a contemporary cultural critique of societal issues surrounding reproduction and gender identity.
Salinity gradients exist when two bodies of waters have different salt concentrations. These gradients possess an immense amount of potential energy. For example, the energy contained in the mixing of freshwater and seawater at coasts is equivalent to freshwater flowing over a 270-meter-tall dam into the ocean. In this talk, I will present a recent, battery-inspired technique developed by my group that harvests this energy – the concentration flow cell – and discuss future research directions and collaborative opportunities.
On June 6th over 40 students competed in the 3rd annual Millennium Café Pitch Competition sponsored by PPG. The competition was fierce as students had <2 minutes to introduce their research in a manner that was understandable and inspiring to a diverse panel of judges. Don’t miss this opportunity to hear the top-3 winners from this year’s competition.
In the spirit of the Café, 45 students are competing for the top prize by pitching their research in two minutes or less. Topics range from clean water, nanoscience, medicine, energy, materials, and much more. This is a great opportunity to scout for new collaborations while enjoying a cup of coffee. The competition starts at 10:00 and will be setup similar to a poster session - this enables attendees to individually engage the competitors. Please be mindful of the judges as they need to evaluate every competitor in a short period of time. PPG has once again generously provided funding to enable this fantastic event.
In contrast to traditional two-dimensional cultures, tissue spheroids offer many advantages, such as the ability of cells to secrete their extracellular matrix with an effective communication between them in a native-like microenvironment. Recently, bioprinting of tissue has gained noteworthy attention. In this talk, I will explain a new aspiration-assisted bioprinting method for precise patterning and bioprinting tissue spheroids.
In 1946 Richard Ogg found unusual highly conductive states in the dilute solution of sodium in ammonia. The resistance of the solution dropped by a factor of 1000 when the solution, placed into thin glass capillaries, was first quenched into liquid oxygen and then taken out into 190K atmosphere. Ogg attributed the observed effect to the meta-stable superconductivity. Several groups at different times tried to reproduce the effect, but consensus on the nature of the highly conductive state was not reached. We are trying to resolve the mystery as well as improve quenching technique to explore the meta-stable states of sodium-ammonia solution.
Elucidating the structure and dynamics of polymeric and hybrid materials is an under explored scientific area which needs to be addressed to solve various challenging problems in material and biological sciences. Wide and Small-Angle X-ray Scattering (WAXS/SAXS) techniques allow probing the structure of materials at a wide range of length scales. The new scattering techniques (WAXS/SAXS/GIWAXS/GISAXS) recently installed at the Materials Characterization Lab (MCL) are now available to support a diverse cross-section of researchers investigating a wide range of systems including polymers and biomaterials. The objective of this talk is to briefly describe the capabilities of the new technique and to promote collaboration among researchers in different disciplines.
The Millennium Café began on May 22, 2012 as an experiment to increase the frequency of constructive collisions between historically disparate disciplines. Since that first Tuesday nearly 20,000 curious researchers have consumed >3500 gallons of top shelf coffee and 35,000 assorted pastries in the spirit of interdisciplinary research. The Café experiment has been successful - new research collaborations are frequently catalyzed and the Cafe enhances an already excellent culture of interdisciplinary research at Penn State. Join us as we celebrate and brainstorm ideas to further enrich the Café over the next five years.
The ability to accurately predict falls risk could allow individuals at risk to receive appropriate gait retraining before they fall and injure themselves. Using methods from the field of legged robotics, I have developed a predictive simulation of human walking that can be used to investigate falls risk.
Plate tectonics provides a unifying theory to explain the motion of rigid plates on Earth’s surface. However, the rates at which tectonic forces flux heat and mass through plate boundary zones (i.e. subduction zones and rifts) are still poorly understood. In this talk, I will summarize recent work from our research group on the use of diffusion theory applied to crustal minerals to constrain rates of plate boundary deformation and metamorphism