Guarding the genome: Researchers uncover full 3D structure of p53 protein

By Mariah R. Lucas

UNIVERISTY PARK, Pa. — The tumor suppressor protein p53, known as "the guardian of the genome," protects the body’s DNA from daily stress or long-term damage by triggering the cells to make repairs or to self-destruct. But mutations in the p53 gene that codes for the protein can prevent it from performing its job, making errors accumulate in the genetic code and leading to diseases like cancer.

Researchers 3D bioprint breast cancer tumors, treat them in groundbreaking study

Bioprinting Breast Cancer Tumor

By Adrienne Berard

Researchers at Penn State have successfully 3D bioprinted breast cancer tumors and treated them in a breakthrough study to better understand the disease that is one of the leading causes of mortality worldwide.

A scientific first, the achievement lays the foundation for precision fabrication of tumor models. The advancement will enable future study and development of anti-cancer therapies without the use of "in vivo" — or "in animal" — experimentation.

Deb Kelly

Deb Kelly

Professor of Biomedical Engineering Director, Center for Structural Oncology

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506 Chemical and Biomedical Engineering Building
James Adair

James Adair

Professor of Materials Science and Engineering Biomedical Engineering and Pharmacology

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407 Steidle Building