Mutations in ATP13A2 cause juvenile onset Parkinson’s disease and other neurodegenerative diseases. My lab leverages an electron cryo-microscopy technique called single-particle analysis (SPA) to study mechanisms of membrane transport. I will present atomic structures of human ATP13A2 visualized by SPA that reveal physical principles underlying selective polyamine transport and its regulation by lipids. These findings bring us closer to realizing ATP13A2’s potential in neuroprotective therapy.
Presenter: Kenneth Lee | Cellular and Molecular Physiology