In situ analysis of bacterial response to various environmental stressors is fundamentally important in fields ranging from life sciences to generation of sustainable energy using microbial fuels. Being scalable, electronic/electrochemical sensing can enable label-free analysis of bacterial behavior to stress, in situ.  In this talk, I will discuss how the response of bacterial cells to stress (osmotic and heat stress as examples) can be monitored using time-dependent impedance spectroscopy, highlight some of the unanswered questions, and how collaboration can hopefully provide new insights.