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A cheap, disposable device for diagnosing disease

Wednesday, December 2, 2015

The development of a reusable microfluidic device for sorting and manipulating cells and other micro/nano meter scale objects will make biomedical diagnosis of diseases cheaper and more convenient in regions where medical facilities are sparse or cost is prohibitive. Researchers at Penn State have recently filed a patent to develop such a device.

Based on gentle acoustic vibrations, the device, called acoustic tweezers, is the work of Penn State professor of engineering science and mechanics, Tony Huang and his students. Their work is the cover article for the current issue of the journal Lab on a Chip.

"We believe our acoustic tweezers have tremendous potential, especially in diagnostics, with some applications also in therapeutics," Huang said. "Our current device works well, but to be used in diagnostics, the whole device has to be disposed of after one use. We have now found a way to separate the fluid-containing part of the device from the much more expensive ultrasound-producing piezoelectric substrate. This makes disposable acoustic tweezers possible."

Huang believes that the disposable plastic portion of the device can be manufactured for as little as 25 cents per unit. Even with the addition of electronics for diagnosis, which could be easily added off the shelf, he foresees a manufacturing cost of a few dollars for the complete permanent system, which could then be used over and over with the simple replacement of the plastic microfluidic channels.