TOF-SIMS image

Time of Flight Secondary Ion Mass Spectrometry (ToF-SIMS) is a surface characterization, micro-analysis technique which is based upon the liberation and identification of ions that are sputtered from a sample’s surface. This method is extremely surface sensitive since most of the liberated material comes from the top-most surface layers, yet it also has the capability to selectively etch away material and perform in-depth analyses. The data provide molecular and elemental information about a wide variety of materials.

With this technique, the sample surface is interrogated with a pulsed beam of high energy primary ions. These ions have sufficient energy to both sputter and ionize atoms and molecules in the surface at and near the ion impact location. The newly formed secondary ions are accelerated into an analyzer where they are separated according to their mass-to-charge ratios. The mass-to-charge ratio is used to identify the elemental and chemical species present in the sample. Molecular fragmentation patterns and isotope ratios aid in the identification of many species in complex matrices. Two and three dimensional elemental and molecular maps can be generated with sub-micron spatial resolution.

Ion images
Ion Images

The ion images of a potential biomarker are superimposed on optical microscopy images in order to visualize the molecule's distribution in non-infected (left) and infected (right) mouse tissue

Depth profiles
Depth Profile

Positive-ion depth profile of a manufactured float (i.e. soda-lime) glass surface

Technical Poster
TOF-SIMS Technical Poster
Technical Poster
SIMS Technical Poster
  • Bi LMIG for spectroscopy, imaging, and etching
  • 2D and 3D imaging capabilities
  • Lateral imaging resolution down to ~100 nm
  • Argon gas-cluster ion gun for organic depth profiling or sample cleaning
  • Gas gun for etching with either argon or oxygen
  • Mass resolution typically 4000-8000 (m/Δm) provides molecular and elemental information
  • Depth profile analysis
  • Dual charge neutralization facilitates analyses of electrically insulating materials
  • Inert environment sample transfer vessel
  • Cold stage and glovebox for analyses of frozen-hydrated biological materials
  • Sample cooling/heating from -150 to 600ºC
  • Instrumentation: PHI nanoTOF II
  • 2D and 3D elemental and chemical distributions
  • Biological materials (native state, freeze dried, or frozen hydrated)
  • Organic and inorganic films
  • Polymers
  • Semiconductors and electronic materials
  • Metals
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